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Saturday, July 18, 2020 | History

5 edition of Aldo-Keto Reductases and Toxicant Metabolism (Acs Symposium Series) found in the catalog.

Aldo-Keto Reductases and Toxicant Metabolism (Acs Symposium Series)

  • 15 Want to read
  • 38 Currently reading

Published by An American Chemical Society Publication .
Written in English

    Subjects:
  • Science/Mathematics,
  • Metabolic detoxification,
  • Chemistry - Clinical,
  • Science,
  • Medical / Nursing,
  • Biochemistry,
  • Medical / Biochemistry,
  • Science / Chemistry / Clinical,
  • Science-Chemistry - Clinical,
  • Carbonyl reductase,
  • Congresses

  • Edition Notes

    ContributionsTrevor M. Penning (Editor), J. Mark Petrash (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages272
    ID Numbers
    Open LibraryOL8227127M
    ISBN 100841238464
    ISBN 109780841238466

    This study was based on the premise that inhibition of aldo‐keto reductases would improve the efficacy of doxorubicin by reducing its toxic metabolites and modifying its pharmacokinetics. We assessed the effect of in‐vitro inhibition of aldo‐keto reductases on the metabolism of doxorubicin in cytosolic fractions of heart and liver of rats. Books for Courses (8) Professional / Practitioner (26) Publication Date. Last 3 Months (1) Ongoing Publication (2) Price. Under $15 (1) Aldo-Keto Reductases and Toxicant Metabolism $ Add Aldo-Keto Reductases and Toxicant Metabolism to Cart. Trevor M. Penning and J. Mark Petrash. Hardcover.

    Aldo-keto reductases (AKRs) are part of the oxidoreductase super family and play an important role in the cellular response to electrophilic, osmotic, and oxidative stress, depending on the. Analysis of etheno 2’-deoxyguanosine adducts as dosimeters of AKR mediated-oxidative stress (Chapter 10) in Aldo-keto reductases and toxicant metabolism (ACS Symposium Series ), pp[Oxford University Press,()]Lee, S.H., Blair, I.A. ISBN 3.

    Research on Aldo-keto reductases (AKRs) over the years has revealed a remarkable diversity in the reactivity of these soluble NAD(P)(H) oxidoreductases. The AKR enzymes primarily catalyze the reduction of aldehydes and ketones to primary and secondary alcohols, respectively. Aldo-keto reductases (AKRs) are widely distributed in nature and play numerous roles in the metabolism of steroids, sugars, and other carbonyls. They have also frequently been implicated in the metabolism of exogenous and endogenous toxicants, including those stimulated by stress.


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Aldo-Keto Reductases and Toxicant Metabolism (Acs Symposium Series) Download PDF EPUB FB2

Aldo-Keto Reductases and Toxicant Metabolism provides an overview of the rapidly growing Aldo-Keto Reductase (AKR) superfamily and its role in the metabolism of endogenous and exogenous toxicants.

This book discusses the ability of AKRs to metabolize endogenous toxicants including: sugar aldehydes, advanced glycosylation end products, and lipid aldehydes (products of. Aldo-Keto Reductases and Toxicant Metabolism shows how evolutionary AKRs are conserved in prokaryotes through eukaroytes and can thus be considered primordial genes.

They are also regulated by primordial stress signals (osmotic stress, reactive oxygen species, and electrophiles) to respond to toxic : $ Description.

Aldo-Keto Reductases and Toxicant Metabolism provides an overview of the rapidly growing Aldo-Keto Reductase (AKR) superfamily and its role in the metabolism of endogenous and exogenous toxicants.

This book discusses the ability of AKRs to metabolize endogenous toxicants including: sugar aldehydes, advanced glycosylation end products, and lipid aldehydes (products of.

Aldo-Keto Reductases and Toxicant Metabolism provides an overview of the rapidly growing Aldo-Keto Reductase (AKR) superfamily and its role in the metabolism of endogenous and exogenous toxicants.

This book discusses the ability of AKRs to metabolize endogenous toxicants including: sugar aldehydes, advanced glycosylation end products, and lipid aldehydes (products of lipid peroxidation. Aldo-Keto Reductases and Toxicant Metabolism | Trevor M. Penning and J. Mark Petrash (Eds.) | download | B–OK.

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This book. Open Library is an open, editable library catalog, building towards a web page for every book ever published. Aldo-keto reductases and toxicant metabolism by Trevor M. Penning,American Chemical Society edition, in English.

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Aldo-Keto Reductases and Toxicant Metabolism By Trevor M. Penning and J. Mark Petrash (Eds.) | Pages | ISBN: | PDF | 25 MB. Chapter Views are the COUNTER-compliant sum of full text article downloads since November (both PDF and HTML) across all institutions and individuals. Aldo-Keto Reductases and Toxicant Metabolism edited by Trevor M.

Penning and J. Mark Petrash. This book discusses the role of the Aldo-Keto Reductase (AKR) superfamily in the metabolism of endogenous and exogenous toxicants.

Aldo-keto reductases (AKRs) are a major superfamily of NAD(P)H-dependent oxidoreductases. They use a conserved catalytic mechanism and rate is often governed by cofactor release. There are 15 human AKRs implicated in health and disease. Inhibitor programs exist world-wide to develop therapeutics and chemical probes for AKRs.

Buy Aldo-Keto Reductases and Toxicant Metabolism Books online at best prices in India by J. Mark Petrash,Trevor M. Penning,Trevor M Penning,J Mark Petrash from Buy Aldo-Keto Reductases and Toxicant Metabolism online of India’s Largest Online Book Store, Only Genuine Products.

Lowest price and Replacement Guarantee. Cash On Delivery Available. Aldo-Keto Reductases and Toxicant Metabolism provides an overview of the rapidly growing Aldo-Keto Reductase (AKR) superfamily and its role in the metabolism of endogenous and exogenous toxicants.

This book discusses the ability of AKRs to metabolize endogenous toxicants including: sugar aldehydes, advanced glycosylation end products, and lipid.

Aldo-keto reductases and exogenous toxicants: tobacco-related carcinogens --Competing roles of reductases in the detoxification of the tobacco-specific nitrosamine ketone NNK / Edmund Maser --Aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons / Trevor M.

Penning --Molecular cloning and characterization of. NEXT BOOK; VIEW ALL BOOKS ALL BOOKS; Aldo-Keto Reductases and Toxicant Metabolism.

Editor(s): Trevor M. Penning 1; J. Mark Petrash 2; Volume. Buy (ALDO-KETO REDUCTASES AND TOXICANT METABOLISM) BY Petrash, J. Mark(Author)Hardcover on (10, ) by Petrash, J. Mark (ISBN:) from Amazon's Book Store. Everyday low prices and free delivery on eligible : J. Mark Petrash.

Aldo-keto reductases and toxicant metabolism. (ACS symposium series; ) by Ed. by Trevor M. Penning and J.

Mark Petrash. American Chemical Society, Hardbound. New Book. Hardbound. Drawn from an August symposium, 15 papers survey recent research on aldo-keto reductases and their involvement in the metabolism of endogenous toxicants and exogenous toxicants.

Aldo-Keto Reductases and Toxicant Metabolism shows how evolutionary AKRs are conserved in prokaryotes through eukaroytes and can thus be considered primordial genes.

They are also regulated by primordial stress signals (osmotic stress, reactive oxygen species, and electrophiles) to respond to .Abstract Aldo–keto reductases (AKRs) are widely distributed in nature and play numerous roles in the metabolism of steroids, sugars, and other carbonyls.

They have also frequently been implicated in the metabolism of exogenous and endogenous toxicants, including those stimulated by stress.Aldo-keto reductases (AKRs) are a gene superfamily whose members catalyze the nicotinamide adenine dinucleotide (phosphate) (reduced) (NAD(P)(H))-dependent interconversion of aldehydes and ketones with primary and secondary alcohols.

AKRs by functionalizing carbonyl groups for subsequent conjugation reactions can be considered Phase I enzymes.